Immunological response to COVID-19 and its role as a predisposing factor in invasive aspergillosis

Immunological response to COVID-19 and its role as a predisposing factor in invasive aspergillosis

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The world is involved with a pandemic coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome click here coronavirus 2.The clinical manifestations of reported COVID-19-associated pulmonary impairments range from asymptomatic infections to a pneumonia-induced acute respiratory distress syndrome that requires mechanical ventilation.Fungal superinfections complicating the clinical course remain underexplored.Angiotensin-converting enzyme 2, the receptor for COVID-19 that is mainly expressed in airway epithelia and lung parenchyma, is considered an important regulator of innate immunity.

With regard to the viral-cell interaction, imbalanced immune regulation between protective and altered responses caused by the exacerbation of inflammatory responses should be considered a major contributor to anodized pearl price xbox secondary pulmonary aspergillosis.In addition, the complex inherited factors, age-related changes, and lifestyle may also affect immune responses.The complication and persistence of invasive aspergillosis have been well described in patients with severe influenza or COVID-19.However, there is a scarcity of information about the immunological mechanisms predisposing patients with COVID-19 to fungal co-infections.

Therefore, this study was conducted to investigate the aforementioned domain.